doi:10.1182/blood-2005-04-1765 APL treatment Italian style: is this the cure?
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منابع مشابه
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The introduction of all-trans retinoic acid (ATRA) and, more recently, arsenic trioxide (ATO) into the therapy of acute promyelocytic leukemia (APL) has revolutionized the management and outcome of this disease. Several treatment strategies using these agents, usually in combination with chemotherapy, but also without or with minimal use of cytotoxic agents, have provided excellent therapeutic ...
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Acute Promyelocytic Leukemia (APL) relapse in the central nervous system (CNS) can be isolated or associated with bone marrow relapse. Management of CNS APL remains a challenge. In this study, we identified an effective therapeutic regimen for CNS APL that consisted of single-reagent intravenous infusion with arsenic trioxide (ATO) preceded and accompanied by mannitol. Seventeen patients with i...
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In this issue of Blood, Martelli et al and El Hajj et al independently report that nucleophosmin-1 (NPM1)-mutant leukemia is particularly vulnerable to a novel strategy combining all-trans retinoic acid (ATRA) with arsenic trioxide (ATO). The era of targeted therapy has seen some of its greatest successes in the hematologic arena (eg, breakpoint cluster region [BCR]/Abelson [ABL] kinase inhibit...
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تاریخ انتشار 2005